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Article

DJ‐1 is present in a large molecular complex in human brain tissue and interacts with α‐synuclein

16 May 2005

Abstract excerpt

DJ-1 is a ubiquitously expressed protein involved in various cellular processes including cell proliferation, RNA-binding, and oxidative stress. Mutations that result in loss of DJ-1 function lead to early onset parkinsonism in humans, and DJ-1 protein is present in pathological lesions of several tauopathies and synucleinopathies. In order to further investigate the role of DJ-1 in human neurodegenerative...

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PMID: 15935068
DOI: 10.1111/j.1471-4159.2005.03145.x

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