Article
Single nucleotide polymorphisms of the prion protein gene (PRNP) in Chinese pig breeds.
Xenotransplantation - 1 Jul 2005
Meng Liping, Zhao Deming, Liu Hongxiang, Yang Jianmin, Ning Zhangyong
Abstract excerpt
Prion diseases (transmissible spongiform encephalopathies, TSE), as a group of fatal neurodegenerative diseases, have affected humans and a variety of other mammals. Although no natural TSE have been documented in pigs, appropriate precautions need to be taken to prevent the iatrogenic spread of prion disease through pig-to-human xenotransplantation. Polymorphisms within the open reading frame (ORF) of the...
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