Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Peripheral S-phase T cells in HIV disease have a central memory phenotype and rarely have evidence of recent T cell receptor engagement.

The Journal of infectious diseases - 1 Jul 2005

Sieg Scott F, Rodriguez Benigno, Asaad Robert, Jiang Wei, Bazdar Douglas A, Lederman Michael M

Abstract excerpt

Heightened proliferation and death of T lymphocytes may play a key role in human immunodeficiency virus (HIV) pathogenesis; however, the mechanism that mediates this effect and the phenotype of the proliferating T cells have not been clearly determined. We assessed S-phase cell frequencies and phenotype by ex vivo bromodeoxyuridine incorporation and flow-cytometric analysis in a group of 35 HIV-infected...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Antiretroviral Therapy, Highly Active

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bromodeoxyuridine

Share to Immunologic Memory

Share to Lymphocyte Activation

Share to Lymphocyte Count

Share to Receptors, Antigen, T-Cell

Share to S Phase

Source

Identifiers

PMID: 15942895
DOI: 10.1086/430620

Genes

CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Peripheral S-phase T cells in HIV disease have a central memory phenotype and rarely have evidence of recent T cell receptor engagement.PMID 15942895Read ↗

Comprehensive Mass Cytometry Analysis of Cell Cycle, Activation, and Coinhibitory Receptors Expression in CD4 T Cells from Healthy and HIV‐Infected IndividualsSemantic proximity Read ↗

Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection.Semantic proximity Read ↗

HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and MortalitySemantic proximity Read ↗

CD4+Ki67+ lymphocytes in HIV-infected patients are effector T cells accumulated in the G1 phase of the cell cycleSemantic proximity Read ↗

Phenotypic and functional characterization of HIV-1-specific CD4+CD8+ double-positive T cells in early and chronic HIV-1 infection.Semantic proximity Read ↗

The effect of leflunomide on cycling and activation of T-cells in HIV-1-infected participants.Semantic proximity Read ↗

Defective Human Immunodeficiency Virus-Specific CD8 <sup>+</sup> T-Cell Polyfunctionality, Proliferation, and Cytotoxicity Are Not Restored by Antiretroviral TherapySemantic proximity Read ↗

HIV-1 infection impairs cell cycle progression of CD4+ T cells without affecting early activation responsesSemantic proximity Read ↗

Sirolimus reduces T cell cycling, immune checkpoint marker expression, and HIV-1 DNA in people with HIVSemantic proximity Read ↗

Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection.Semantic proximity Read ↗

Double-Negative T Cell Number and Phenotype Alterations Before and After Effective Antiretroviral Treatment in Persons Living with HIV.Semantic proximity Read ↗

CD4 and CD8 T Cell Immune Activation during Chronic HIV Infection: Roles of Homeostasis, HIV, Type I IFN, and IL-7Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.