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Article

The effect of leflunomide on cycling and activation of T-cells in HIV-1-infected participants.

PloS one - 3 Aug 2010

Read Sarah W, DeGrezia Mary, Ciccone Emily J, DerSimonian Rebecca, Higgins Jeanette, Adelsberger Joseph W, Starling Judith M, Rehm Catherine, Sereti Irini

Abstract excerpt

BACKGROUND: The pathogenesis of immunodeficiency due to human immunodeficiency virus (HIV)-1 is incompletely understood, but immune activation is believed to play a central role. Immunomodulatory agents that decrease immune activation may be useful in the treatment of HIV-1 infection. METHODOLOGY: A randomized, double blind, placebo-controlled pilot study of leflunomide for 28 days was performed in participants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20689824
DOI: 10.1371/journal.pone.0011937
PMCID: PMC2914784

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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