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Article

CD4+Ki67+ lymphocytes in HIV-infected patients are effector T cells accumulated in the G1 phase of the cell cycle

1 Dec 2000

Abstract excerpt

Entry into the cell cycle represents a fundamental step before generating an effector immune response. The relationship between the cell cycle and antigen-driven T cell response remains, however, poorly understood in virus infection, including HIV. We have identified a critical fraction of CD4+CD45RO+ memory T lymphocytes that express the Ki67 antigen in chronically HIV-infected patients. A high accumulation of...

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PMID: 11169402
DOI: 10.1002/1521-4141(200012)30:12<3598::aid-immu3598>3.0.co;2-e

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