Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of the lineage relationship between mast cells and basophils using the c-kit D816V mutation as a biologic signature.

The Journal of allergy and clinical immunology - 1 Jun 2005

Kocabas Can N, Yavuz Akif S, Lipsky Peter E, Metcalfe Dean D, Akin Cem

Abstract excerpt

BACKGROUND: Mast cells and basophils share similar morphologic and functional properties; however, it is not known whether they are derived from a bilineage (basophil/mast cell)-restricted progenitor. OBJECTIVE: To assess whether basophils and mast cells are derived from common committed progenitors using the c-kit D816V mutation as a biologic signature. METHODS: The D816V c-kit mutation found in mast cells of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basophils
Share to Cell Lineage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mast Cells

Share to Mastocytosis

Share to Mutation

Share to Polymorphism, Restriction Fragment Length

Share to Stem Cell Factor

Source

Identifiers

PMID: 15940128
DOI: 10.1016/j.jaci.2005.02.030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of the lineage relationship between mast cells and basophils using the c-kit D816V mutation as a biologic signature.PMID 15940128Read ↗

Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene.Semantic proximity Read ↗

Single-cell analysis reveals the <i>KIT</i> D816V mutation in hematopoietic stem and progenitor cells in systemic mastocytosis: Supplementary dataSemantic proximity Read ↗

KITD816V mutation in blood for the diagnostic screening of systemic mastocytosis and mast cell activation syndromes.Semantic proximity Read ↗

An immature immunophenotype of bone marrow mast cells predicts for multilineage D816V KIT mutation in systemic mastocytosis.Semantic proximity Read ↗

Mastocytosis associated with a rare germline KIT K509I mutation displays a well-differentiated mast cell phenotype.Semantic proximity Read ↗

KIT D816V–mutated bone marrow mesenchymal stem cells in indolent systemic mastocytosis are associated with disease progressionSemantic proximity Read ↗

Mast cells from different molecular and prognostic subtypes of systemic mastocytosis display distinct immunophenotypes.Semantic proximity Read ↗

Myelomastocytic overlap syndromes: biology, criteria, and relationship to mastocytosis.Semantic proximity Read ↗

Characterization of CD34+ hematopoietic cells in systemic mastocytosis: Potential role in disease dissemination.Semantic proximity Read ↗

Mast Cell-Lineage Versus Basophil Lineage Involvement in Myeloproliferative and Myelodysplastic Syndromes: Diagnostic Role of Cell-Immunopheno typingSemantic proximity Read ↗

KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients.Semantic proximity Read ↗

Molecular profiling of myeloid progenitor cells in multi-mutated advanced systemic mastocytosis identifies KIT D816V as a distinct and late event.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.