Article

Single-cell analysis reveals the <i>KIT</i> D816V mutation in hematopoietic stem and progenitor cells in systemic mastocytosis: Supplementary data

2018-08-28

Abstract excerpt

<h4>Background: </h4> Systemic mastocytosis (SM) is a hematological disease characterized by organ infiltration by neoplastic mast cells. Almost all SM patients have a mutation in the gene encoding the tyrosine kinase receptor KIT causing a D816V substitution and autoactivation of the receptor. Mast cells and CD34 + hematopoietic progenitors can carry the mutation, however, in which progenitor cell subset the mut...

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Literature Corpus work: 7b84f88b-c5c0-5c86-848a-44a7f104f720
DOI: 10.1101/394304

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