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Article

Nitric oxide synthase II suppresses the growth and metastasis of human cancer regardless of its up-regulation of protumor factors.

Proceedings of the National Academy of Sciences of the United States of America - 14 Jun 2005

Le Xiangdong, Wei Daoyan, Huang Suyun, Lancaster Jack R, Xie Keping

Abstract excerpt

Inducible nitric oxide (NO) synthase (NOS) II has been implicated in macrophage-mediated antitumor activity. However, use of the NOS II gene in cancer therapy is problematic because of the double-edged nature of NO action. Herein we show that adenoviral vectors mediated effective NOS II gene transfer into various human tumors. Production of NO significantly up-regulated multiple angiogenic molecules. However, the...

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Identifiers

PMID: 15939886
DOI: 10.1073/pnas.0409581102
PMCID: PMC1150810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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