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Article

Genetic regulation of vesiculogenesis and immunomodulation in <i>Mycobacterium tuberculosis</i>

18 Nov 2013

Abstract excerpt

Significance Bacteria stimulate host cells in part via secreted products, some of which are packaged in membrane vesicles (MV). MV released by the major human pathogen Mycobacterium tuberculosis (Mtb) carry lipoprotein LpqH, a major agonist for host Toll-like receptor 2 (TLR2). This study identifies a gene, rv0431 , which appears to regulate mycobacterial MV formation, and therefore we suggest it be named...

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PMID: 24248369
DOI: 10.1073/pnas.1320118110

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