Article
A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
Journal of bacteriology - 1 Jun 2005
Senadheera M Dilani, Guggenheim Bernard, Spatafora Grace A, Huang Yi-Chen Cathy, Choi Jison, Hung David C I, Treglown Jennifer S, Goodman Steven D, Ellen Richard P, Cvitkovitch Dennis G
Abstract excerpt
Bacteria exposed to transient host environments can elicit adaptive responses by triggering the differential expression of genes via two-component signal transduction systems. This study describes the vicRK signal transduction system in Streptococcus mutans. A vicK (putative histidine kinase) deletion mutant (SmuvicK) was isolated. However, a vicR (putative response regulator) null mutation was apparently lethal,...
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