Article
In vitro manganese-dependent cross-talk between Streptococcus mutans VicK and GcrR: implications for overlapping stress response pathways.
PloS one - 1 Jan 2014
Downey Jennifer S, Mashburn-Warren Lauren, Ayala Eduardo A, Senadheera Dilani B, Hendrickson Whitney K, McCall Lathan W, Sweet Julie G, Cvitkovitch Dennis G, Spatafora Grace A, Goodman Steven D
Abstract excerpt
Streptococcus mutans, a major acidogenic component of the dental plaque biofilm, has a key role in caries etiology. Previously, we demonstrated that the VicRK two-component signal transduction system modulates biofilm formation, oxidative stress and acid tolerance responses in S. mutans. Using in vitro phosphorylation assays, here we demonstrate for the first time, that in addition to activating its cognate...
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