Article
Downregulation of GbpB, a component of the VicRK regulon, affects biofilm formation and cell surface characteristics of Streptococcus mutans.
Infection and immunity - 1 Feb 2011
Duque Cristiane, Stipp Rafael N, Wang Bing, Smith Daniel J, Höfling José F, Kuramitsu Howard K, Duncan Margaret J, Mattos-Graner Renata O
Abstract excerpt
The virulence of the dental caries pathogen Streptococcus mutans relies in part on the sucrose-dependent synthesis of and interaction with glucan, a major component of the extracellular matrix of tooth biofilms. However, the mechanisms by which secreted and/or cell-associated glucan-binding proteins (Gbps) produced by S. mutans participate in biofilm growth remain to be elucidated. In this study, we further...
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