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Article

Pneumococcal HtrA protease mediates inhibition of competence by the CiaRH two-component signaling system.

Journal of bacteriology - 1 Jun 2005

Sebert M E, Patel K P, Plotnick M, Weiser J N

Abstract excerpt

Activation of the CiaRH two-component signaling system prevents the development of competence for genetic transformation in Streptococcus pneumoniae through a previously unknown mechanism. Earlier studies have shown that CiaRH controls the expression of htrA, which we show encodes a surface-expressed serine protease. We found that mutagenesis of the putative catalytic serine of HtrA, while not impacting the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15937159
DOI: 10.1128/JB.187.12.3969-3979.2005
PMCID: PMC1151733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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