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Article

Interleukin-1-deficient mice exhibit high sensitivity to gut-derived sepsis caused by Pseudomonas aeruginosa.

Cytokine - 21 Jun 2005

Horino Tetsuya, Matsumoto Tetsuya, Uramatsu Masashi, Tanabe Masaaki, Tateda Kazuhiro, Miyazaki Shuichi, Nakane Akio, Iwakura Yoichiro, Yamaguchi Keizo

Abstract excerpt

BACKGROUND: The role of interleukin (IL)-1 in infectious diseases is controversial; some investigators indicated an enhancing effect of IL-1 on host resistance whereas others demonstrated the protective role of IL-1 receptor antagonist in infection. We evaluated the role of endogenous IL-1 in gut-derived sepsis caused by Pseudomonas aeruginosa, by comparing IL-1-deficient mice and wild-type (WT) mice. METHODS:...

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Identifiers

PMID: 15935954
DOI: 10.1016/j.cyto.2005.01.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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