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Article

Pheno-RNA, a method to associate genes with a specific phenotype, identifies genes linked to cellular transformation.

Proceedings of the National Academy of Sciences of the United States of America - 17 Nov 2020

Darwiche Rabih, Struhl Kevin

Abstract excerpt

Cellular transformation is associated with dramatic changes in gene expression, but it is difficult to determine which regulated genes are oncogenically relevant. Here we describe Pheno-RNA, a general approach to identifying candidate genes associated with a specific phenotype. Specifically, we generate a "phenotypic series" by treating a nontransformed breast cell line with a wide variety of molecules that...

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Share to Biological Variation, Population
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Cell Transformation, Neoplastic

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Share to Gene Expression Regulation, Neoplastic

Share to Transformation, Genetic

Source

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Identifiers

PMID: 33144504
DOI: 10.1073/pnas.2014165117
PMCID: PMC7682411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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