Article
The functional polymorphism in the matrix metalloproteinase-7 promoter increases susceptibility to esophageal squamous cell carcinoma, gastric cardiac adenocarcinoma and non-small cell lung carcinoma.
Carcinogenesis - 1 Oct 2005
Zhang Jianhui, Jin Xia, Fang Shumei, Wang Rui, Li Yan, Wang Na, Guo Wei, Wang Yimin, Wen Denggui, Wei Lizhen, Dong Zhiming, Kuang Gang
Abstract excerpt
An A to G transition at the 181 base pair position upstream of the transcription initiation site of the matrix metalloproteinase-7 (MMP-7) gene (-181A/G) may modify the development and progression of some diseases via influencing the transcription activity of the promoter. To assess the effects of the functional single nucleotide polymorphism on cancer susceptibility and progression, the MMP-7 -181A/G genotypes...
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