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Article

Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.

The Journal of biological chemistry - 29 Jul 2005

Young David B, Jonnalagadda Jyoti, Gatei Magtouf, Jans David A, Meyn Stephen, Khanna Kum Kum

Abstract excerpt

Ataxia-telangiectasia mutated (ATM) is essential for rapid induction of cellular responses to DNA double strand breaks (DSBs). In this study, we mapped a nuclear localization signal (NLS), 385KRKK388, within the amino terminus of ATM and demonstrate its recognition by the conventional nuclear import receptor, the importin alpha1/beta1 heterodimer. Although mutation of this NLS resulted in green fluorescent...

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Source

Identifiers

PMID: 15929992
DOI: 10.1074/jbc.M411689200

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.PMID 15929992Read ↗

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.Semantic proximity Read ↗

DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.Semantic proximity Read ↗

Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1.Semantic proximity Read ↗

Differential localization of ATM is correlated with activation of distinct downstream signaling pathwaysSemantic proximity Read ↗

Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functionsSemantic proximity Read ↗

ATM modulates nuclear mechanics by regulating lamin A levelsSemantic proximity Read ↗

ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia.Semantic proximity Read ↗

A new role for ATMSemantic proximity Read ↗

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.Semantic proximity Read ↗

Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.Semantic proximity Read ↗

Recombinant ATM protein complements the cellular A-T phenotype.Semantic proximity Read ↗

The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damageSemantic proximity Read ↗

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