Article
Genomic analysis of Drosophila chromosome underreplication reveals a link between replication control and transcriptional territories.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2005
Belyakin Stepan N, Christophides George K, Alekseyenko Artyom A, Kriventseva Evgenia V, Belyaeva Elena S, Nanayev Roman A, Makunin Igor V, Kafatos Fotis C, Zhimulev Igor F
Abstract excerpt
In Drosophila polytene chromosomes, most late-replicating regions remain underreplicated. A loss-of-function mutant of the suppressor of underreplication [Su(UR)] gene suppresses underreplication (UR), whereas extra copies of this gene enhance the level and number of regions showing UR. By combining DNA microarray analysis with manipulation of the number of Su(UR) gene copies, we achieved genomic-scale molecular...
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