Article
Effects of Mutations in the Drosophila melanogaster Rif1 Gene on the Replication and Underreplication of Pericentromeric Heterochromatin in Salivary Gland Polytene Chromosomes.
Cells - 19 Jun 2020
Kolesnikova Tatyana D, Kolodyazhnaya Alexandra V, Pokholkova Galina V, Schubert Veit, Dovgan Viktoria V, Romanenko Svetlana A, Prokopov Dmitry Yu, Zhimulev Igor F
Abstract excerpt
In Drosophila salivary gland polytene chromosomes, a substantial portion of heterochromatin is underreplicated. The combination of mutations SuURES and Su(var)3-906 results in the polytenization of a substantial fraction of unique and moderately repeated sequences but has almost no effect on satellite DNA replication. The Rap1 interacting factor 1 (Rif) protein is a conserved regulator of replication timing, and...
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