Article
Suppressive functions of activated B cells in autoimmune diseases reveal the dual roles of Toll-like receptors in immunity.
Immunological reviews - 1 Jan 2010
Lampropoulou Vicky, Calderon-Gomez Elisabeth, Roch Toralf, Neves Patricia, Shen Ping, Stervbo Ulrik, Boudinot Pierre, Anderton Stephen M, Fillatreau Simon
Abstract excerpt
B lymphocytes contribute to immunity through production of antibodies, antigen presentation to T cells, and secretion of cytokines. B cells are generally considered in autoimmune diseases as drivers of pathogenesis. This view is certainly justified, given the successful utilization of the B cell-depleting reagent rituximab in patients with rheumatoid arthritis or other autoimmune pathologies. In a number of...
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