Article
Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product.
Genes & development - 1 Jun 1992
Naeger L K, Schoborg R V, Zhao Q, Tullis G E, Pintel D J
Abstract excerpt
mRNAs R1 and R2 of the autonomous parvovirus minute virus of mice (MVM), which encode the viral nonstructural proteins NS1 and NS2, respectively, are processed in an ordered splicing pathway in which R2 is generated from mature spliced R1. Introduction of translation termination signals into these genes alters the processing of these RNAs; there is a significant (up to fourfold) increase in the accumulated...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Cell Line
- Exons
- Mice
- Minute Virus of Mice
- Molecular Sequence Data
- Mutation
- RNA Splicing
- RNA, Messenger