Article
Genetic interactions between CDC7 and CDC28: growth inhibition of cdc28-1N by Cdc7 point mutants.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Oct 1996
Ohtoshi A, Arai K, Masai H
Abstract excerpt
BACKGROUND: Cdc7 kinase of Saccharomyces cerevisiae, a nuclear phosphoprotein, regulates initiation of chromosomal DNA replication. Overexpression of kinase-negative Cdc7 point mutants (T281E, D182N and D163N) arrests the cell cycle of the wild-type Saccharomyces cerevisiae cells at the G1/S boun...
Topics
- CDC28 Protein Kinase, S cerevisiae
- Cell Cycle Proteins
- Cell Division
- DNA Replication
- G1 Phase
- Phenotype
- Phosphoproteins
- Ploidies
- Point Mutation
- Protein Kinases
- Protein Serine-Threonine Kinases
- S Phase
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Temperature