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Article

Genetic interactions between CDC7 and CDC28: growth inhibition of cdc28-1N by Cdc7 point mutants.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Oct 1996

Ohtoshi A, Arai K, Masai H

Abstract excerpt

BACKGROUND: Cdc7 kinase of Saccharomyces cerevisiae, a nuclear phosphoprotein, regulates initiation of chromosomal DNA replication. Overexpression of kinase-negative Cdc7 point mutants (T281E, D182N and D163N) arrests the cell cycle of the wild-type Saccharomyces cerevisiae cells at the G1/S boundary. This is caused by titration of a regulatory protein, Dbf4, from the wild-type Cdc7, which leads to inactivation...

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Source

Identifiers

PMID: 9077449
DOI: 10.1046/j.1365-2443.1996.d01-212.x

Genes

CDC7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic interactions between CDC7 and CDC28: growth inhibition of cdc28-1N by Cdc7 point mutants.PMID 9077449Read ↗

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