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Article

Modulation of astrocyte phenotype in response to T-cell interaction.

Journal of neuroimmunology - 15 Feb 2021

Hersh Jessica, Prah Jude, Winters Ali, Liu Ran, Yang Shao-Hua

Abstract excerpt

We determined that T-cell astrocyte interaction modulates interleukin-10 (IL-10) production from both cell types. The impact of IL-10 on astrocytes was compared to IL-10 generated from T-cell-astrocyte interactions in vitro. We demonstrated that T-cells directly interact with astrocytes to upregulate gene expression and secretion of IL-10, confirmed by elevated STAT3p/STAT3 expression in astrocytes. IL-10...

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Identifiers

PMID: 33370671
DOI: 10.1016/j.jneuroim.2020.577455
PMCID: PMC7856103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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