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Article

Aberrant phenotypes of transgenic mice expressing dimeric human erythropoietin.

Reproductive biology and endocrinology : RB&E - 27 Jan 2012

Yun Seong-Jo, Naidansuren Purevjargal, Sim Bo-Woong, Park Jong-Ju, Park Cha-Won, Nanjidsuren Tseeleema, Kang Myung-Hwa, Hwang Sue-Yun, Yoon Jong-Taek, Min Kwan-Sik

Abstract excerpt

BACKGROUND: Dimeric human erythropoietin (dHuEPO) peptides are reported to exhibit significantly higher biological activity than the monomeric form of recombinant EPO. The objective of this study was to produce transgenic (tg) mice expressing dHuEPO and to investigate the characteristics of these mice. METHODS: A dHuEPO-expressing vector under the control of the goat beta-casein promoter, which produced a dimer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22284751
DOI: 10.1186/1477-7827-10-6
PMCID: PMC3284390

Genes

EPO

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