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Article

Calpain A modulates Toll responses by limited Cactus/IκB proteolysis.

Molecular biology of the cell - 1 Sept 2013

Fontenele Marcio, Lim Bomyi, Oliveira Danielle, Buffolo Márcio, Perlman David H, Schupbach Trudi, Araujo Helena

Abstract excerpt

Calcium-dependent cysteine proteases of the calpain family are modulatory proteases that cleave their substrates in a limited manner. Among their substrates, calpains target vertebrate and invertebrate IκB proteins. Because proteolysis by calpains potentially generates novel protein functions, it is important to understand how this affects NFκB activity. We investigate the action of Calpain A (CalpA) on the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23864715
DOI: 10.1091/mbc.E13-02-0113
PMCID: PMC3771957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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