Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling.

The Journal of biological chemistry - 30 Jul 2004

Galgani Mario, De Rosa Veronica, De Simone Salvatore, Leonardi Antonio, D'Oro Ugo, Napolitani Giorgio, Masci Anna Maria, Zappacosta Serafino, Racioppi Luigi

Abstract excerpt

Immature dendritic cells (iDCs) can be instructed to polarize the immune response toward a noninflammatory pathway by mediators that increase the intracellular concentration of cAMP. This phenomenon is associated with the ability of the cyclic nucleoside to inhibit the release of pro-inflammatory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 8-Bromo Cyclic Adenosine Monophosphate
Share to Chemotaxis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP-Dependent Protein Kinases

Share to Endotoxins

Share to Interleukin-12

Share to p38 Mitogen-Activated Protein Kinases

Share to Protein Kinase C

Share to src-Family Kinases

Source

Identifiers

PMID: 15166249
DOI: 10.1074/jbc.M403355200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15166249-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling.PMID 15166249Read ↗

The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory DiseasesSemantic proximity Read ↗

Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8(+) T-cell priming capacity.Semantic proximity Read ↗

Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype.Semantic proximity Read ↗

Cyclic AMP Regulates Key Features of Macrophages via PKA: Recruitment, Reprogramming and Efferocytosis.Semantic proximity Read ↗

Cyclic AMP induces activation of extracellular signal-regulated kinases in HL-60 cells: role in cAMP-induced differentiation.Semantic proximity Read ↗

A forskolin-mediated increase in cAMP promotes T helper cell differentiation into the Th1 and Th2 subsets rather than into the Th17 subsetSemantic proximity Read ↗

Prostaglandin E2 and other cyclic AMP-elevating agents modulate IL-2 and IL-2R α gene expression at multiple levelsSemantic proximity Read ↗

Repression of class II major histocompatibility complex genes by cyclic AMP is mediated by conserved promoter elements.Semantic proximity Read ↗

HIF-dependent induction of adenosine receptor A2b skews human dendritic cells to a Th2-stimulating phenotype under hypoxia.Semantic proximity Read ↗

Apoptotic signaling through the beta -adrenergic receptor. A new Gs effector pathway.Semantic proximity Read ↗

PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway.Semantic proximity Read ↗

Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle alpha2C-adrenoceptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.