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Article

The SPINK1 N34S mutation is not associated with Type 2 diabetes mellitus in a population of the USA.

Diabetic medicine : a journal of the British Diabetic Association - 1 Jun 2005

Schneider A, Lawrence E C, Barmada M M, Norris J M, Hamman R F, Marshall J A, Ferrell R E, Whitcomb D C

Abstract excerpt

AIMS: Mutations in the serine protease inhibitor (SPINK1) gene have been associated with all forms of chronic pancreatitis. Recently, an association of SPINK1 mutations with early-onset Type 2 diabetes mellitus has been reported in patients from Bangladesh. Therefore, we determined the frequency of SPINK1 N34S mutations in patients with Type 2 diabetes mellitus from the USA. METHODS: The study population of...

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Share to Chronic Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

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Share to Pancreatitis

Share to Trypsin Inhibitor, Kazal Pancreatic

Source

Identifiers

PMID: 15910626
DOI: 10.1111/j.1464-5491.2005.01513.x

Genes

SPINK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The SPINK1 N34S mutation is not associated with Type 2 diabetes mellitus in a population of the USA.PMID 15910626Read ↗

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SPINK1/PSTI mutations are associated with tropical pancreatitis and type II diabetes mellitus in Bangladesh.Semantic proximity Read ↗

The SPINK1 N34S variant is associated with acute pancreatitis.Semantic proximity Read ↗

Study of a panel of genetic mutations in fibrocalcific pancreatic diabetes (FCPD): SPINK1 (N34S) mutation unlikely to be relevant.Semantic proximity Read ↗

Limited contribution of the SPINK1 N34S mutation to the risk and severity of alcoholic chronic pancreatitis: a report from the United States.Semantic proximity Read ↗

Analysis of PRSS1 and SPINK1 mutations in Korean patients with idiopathic and familial pancreatitis.Semantic proximity Read ↗

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The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease.Semantic proximity Read ↗

<i>SPINK1</i> mutations and phenotypic expression in patients with pancreatitis associated with trypsinogen mutationsSemantic proximity Read ↗

Association of rare SPINK1 gene mutation with another base substitution in chronic pancreatitis patients.Semantic proximity Read ↗

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