Article
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.
Nature genetics - 1 Jun 2005
Stephens Philip, Edkins Sarah, Davies Helen, Greenman Chris, Cox Charles, Hunter Chris, Bignell Graham, Teague Jon, Smith Raffaella, Stevens Claire, O'Meara Sarah, Parker Adrian, Tarpey Patrick, Avis Tim, Barthorpe Andy, Brackenbury Lisa, Buck Gemma, Butler Adam, Clements Jody, Cole Jennifer, Dicks Ed, Edwards Ken, Forbes Simon, Gorton Matthew, Gray Kristian, Halliday Kelly, Harrison Rachel, Hills Katy, Hinton Jonathon, Jones David, Kosmidou Vivienne, Laman Ross, Lugg Richard, Menzies Andrew, Perry Janet, Petty Robert, Raine Keiran, Shepherd Rebecca, Small Alexandra, Solomon Helen, Stephens Yvonne, Tofts Calli, Varian Jennifer, Webb Anthony, West Sofie, Widaa Sara, Yates Andrew, Brasseur Francis, Cooper Colin S, Flanagan Adrienne M, Green Anthony, Knowles Maggie, Leung Suet Y, Looijenga Leendert H J, Malkowicz Bruce, Pierotti Marco A, Teh Bin, Yuen Siu T, Nicholson Andrew G, Lakhani Sunil, Easton Douglas F, Weber Barbara L, Stratton Michael R, Futreal P Andrew, Wooster Richard
Abstract excerpt
We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
Topics
- Aged
- Breast Neoplasms
- Carcinoma, Ductal, Breast
- DNA Mutational Analysis