Article
CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion.
Oncotarget - 6 Oct 2015
Zhou Pengcheng, Erfani Sonia, Liu Zeyi, Jia Changhe, Chen Yecang, Xu Bingwei, Deng Xinyu, Alfáro Jose E, Chen Li, Napier Dana, Lu Michael, Huang Jian-An, Liu Chunming, Thibault Olivier, Segal Rosalind, Zhou Binhua P, Kyprianou Natasha, Horbinski Craig, Yang Xiuwei H
Abstract excerpt
Glioblastoma, one of the most aggressive forms of brain cancer, is featured by high tumor cell motility and invasiveness, which not only fuel tumor infiltration, but also enable escape from surgical or other clinical interventions. Thus, better understanding of how these malignant traits are controlled will be key to the discovery of novel biomarkers and therapies against this deadly disease. Tetraspanin CD151...
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