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Article

RON receptor tyrosine kinase in human gliomas: expression, function, and identification of a novel soluble splice variant

6 Mar 2009

Abstract excerpt

Malignant gliomas are incurable because of their diffuse infiltration of the surrounding brain. The recepteur d'origine nantais (RON) receptor tyrosine kinase is highly expressed in several epithelial cancer types and mediates tumorigenic, pro-invasive as well as metastatic effects. Analyzing RON expression in human gliomas, we found that different splice variants with known oncogenic activity are expressed in...

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PMID: 19519771
DOI: 10.1111/j.1471-4159.2009.06027.x

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