Article
The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands.
Genome research - 1 Nov 2009
Takeshima Hideyuki, Yamashita Satoshi, Shimazu Taichi, Niwa Tohru, Ushijima Toshikazu
Abstract excerpt
Instructive mechanisms are present for induction of DNA methylation, as shown by methylation of specific CpG islands (CGIs) by specific inducers and in specific cancers. However, instructive factors involved are poorly understood, except for involvement of low transcription and trimethylation of histone H3 lysine 27 (H3K27me3). Here, we used methylated DNA immunoprecipitation (MeDIP) combined with a CGI...
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