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Article

On the use of haplotype phylogeny to detect disease susceptibility loci.

BMC genetics - 18 May 2005

Bardel Claire, Danjean Vincent, Hugot Jean-Pierre, Darlu Pierre, Génin Emmanuelle

Abstract excerpt

BACKGROUND: The cladistic approach proposed by Templeton has been presented as promising for the study of the genetic factors involved in common diseases. This approach allows the joint study of multiple markers within a gene by considering haplotypes and grouping them in nested clades. The idea is to search for clades with an excess of cases as compared to the whole sample and to identify the mutations defining...

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Identifiers

PMID: 15904492
DOI: 10.1186/1471-2156-6-24
PMCID: PMC1173100

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