Article
Signal sequence conservation and mature peptide divergence within subgroups of the murine beta-defensin gene family.
Molecular biology and evolution - 1 Mar 2003
Morrison Gillian M, Semple Colin A M, Kilanowski Fiona M, Hill Robert E, Dorin Julia R
Abstract excerpt
Beta-defensins are two exon genes which encode broad spectrum antimicrobial cationic peptides. We have analyzed the largest murine cluster of these genes which localizes to chromosome 8. Using hidden Markov models, we identified six beta-defensin exon 2-like sequences and subsequently found full-length expressed transcripts for these novel genes. Expression was high in brain and reproductive tissues. Eleven...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.