Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Directional and balancing selection in human beta-defensins.

BMC evolutionary biology - 16 Apr 2008

Hollox Edward J, Armour John A L

Abstract excerpt

BACKGROUND: In primates, infection is an important force driving gene evolution, and this is reflected in the importance of infectious disease in human morbidity today. The beta-defensins are key components of the innate immune system, with antimicrobial and cell signalling roles, but also reproductive functions. Here we examine evolution of beta-defensins in catarrhine primates and variation within different...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pair Mismatch
Share to beta-Defensins
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Duplication

Share to Genetics, Population

Share to Macaca

Share to Selection, Genetic

Share to Sequence Analysis, Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 18416833
DOI: 10.1186/1471-2148-8-113
PMCID: PMC2373304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Directional and balancing selection in human beta-defensins.PMID 18416833Read ↗

The complexity of selection at the major primate beta-defensin locus.Semantic proximity Read ↗

Beta-defensin 1 gene variability among non-human primates.Semantic proximity Read ↗

A worldwide analysis of beta-defensin copy number variation suggests recent selection of a high-expressing DEFB103 gene copy in East AsiaSemantic proximity Read ↗

Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations.Semantic proximity Read ↗

The Evolution of Innate Immune Genes: Purifying and Balancing Selection on β-Defensins in Waterfowl.Semantic proximity Read ↗

Antimicrobial functions of lactoferrin promote genetic conflicts in ancient primates and modern humansSemantic proximity Read ↗

Evidence of positively selected sites in mammalian alpha-defensins.Semantic proximity Read ↗

Alpha globin variation in the long-tailed macaque suggests malaria selectionSemantic proximity Read ↗

Diversifying and purifying selection in the peptide binding region of DRB in mammals.Semantic proximity Read ↗

Genome-wide identification and characterization of β-defensin genes across sixteen Eulipotyphla species: Insights into gene diversification and evolutionary dynamics.Semantic proximity Read ↗

Ancient hybridization and strong adaptation to viruses across African vervet monkey populationsSemantic proximity Read ↗

Ancient and recent selective pressures shaped genetic diversity at AIM2-like nucleic acid sensors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.