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Article

BRAF(V600E) mutation in Turkish patients with papillary thyroid cancer: strong correlation with indicators of tumor aggressiveness.

Endocrine - 1 Oct 2012

Kurtulmus Neslihan, Duren Mete, Ince Umit, Cengiz Yakicier M, Peker Onder, Aydın Ozlem, Altiok Ender, Giray Serdar, Azizlerli Halil

Abstract excerpt

Papillary thyroid cancer (PTC) constitutes more than 90% of the thyroid cancers. MAP kinase/ERK pathway plays an important role in the development of several cancers. BRAF which is a member of Raf-kinase family activates this way. BRAF gene activating mutations lead to neoplastic transformation in thyroid follicle cells. In PTC, this mutation itself is a poor prognostic sign independent of other...

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Identifiers

PMID: 22426956
DOI: 10.1007/s12020-012-9651-x

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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