Article
The complex interplay between the neck and hinge domains in kinesin-1 dimerization and motor activity.
Molecular biology of the cell - 1 Aug 2005
Bathe Friederike, Hahlen Katrin, Dombi Renate, Driller Lucia, Schliwa Manfred, Woehlke Guenther
Abstract excerpt
Kinesin-1 dimerizes via the coiled-coil neck domain. In contrast to animal kinesins, neck dimerization of the fungal kinesin-1 NcKin requires additional residues from the hinge. Using chimeric constructs containing or lacking fungal-specific elements, the proximal part of the hinge was shown to stabilize the neck coiled-coil conformation in a complex manner. The conserved fungal kinesin hinge residue W384 caused...
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