Article
Fungal Kti12 proteins display unusual linker regions and unique ATPase p-loops.
Current genetics - 1 Aug 2020
Krutyhołowa Rościsław, Reinhardt-Tews Annekathrin, Chramiec-Głąbik Andrzej, Breunig Karin D, Glatt Sebastian
Abstract excerpt
Kti12 (Kluyveromyces lactis toxin insensitive 12) is an evolutionary highly conserved ATPase, crucial for the tRNA-modification activity of the eukaryotic Elongator complex. The protein consists of an N-terminal ATPase and a C-terminal tRNA-binding domain, which are connected by a flexible linker. The precise role of the linker region and its involvement in the communication between the two domains and their...
Topics
- AAA Domain
- Adaptor Proteins, Signal Transducing
- Amino Acid Substitution
- Animals
- Catalytic Domain
- Evolution, Molecular
- Fungal Proteins
- Killer Factors, Yeast
- Kluyveromyces
- Lysine
- Machine Learning
- Models, Molecular
- Mutation
- Protein Conformation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins