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Article

EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid.

PLoS biology - 1 Nov 2004

Dutt Amit, Canevascini Stefano, Froehli-Hoier Erika, Hajnal Alex

Abstract excerpt

During Caenorhabditis elegans vulval development, the anchor cell (AC) in the somatic gonad secretes an epidermal growth factor (EGF) to activate the EGF receptor (EGFR) signaling pathway in the adjacent vulval precursor cells (VPCs). The inductive AC signal specifies the vulval fates of the three proximal VPCs P5.p, P6.p, and P7.p. The C. elegans Rhomboid homolog ROM-1 increases the range of EGF, allowing the...

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Identifiers

PMID: 15455032
DOI: 10.1371/journal.pbio.0020334
PMCID: PMC519001

Genes

EGF
EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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