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Article

Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factors.

Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Apr 2005

Posthuma Danielle, Meulenbelt Ingrid, de Craen Anton J M, de Geus Eco J C, Slagboom P Eline, Boomsma Dorret I, Westendorp Rudi G J

Abstract excerpt

Through its ability to induce the enhanced release and production of cytokines, amyloid-beta is responsible for the chronic inflammatory response that contributes to Alzheimer's disease (AD). Determining whether the response of monocytes to amyloid-beta stimulation is under genetic control may help understand the basis of why some people are more prone to develop neuronal degeneration than others. In the current...

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PMID: 15901476
DOI: 10.1375/1832427053738728

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TNF

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