Article
Glutathione S-transferase polymorphisms and susceptibility to neuroblastoma.
Pharmacogenetics and genomics - 1 Jun 2005
Lanciotti Marina, Coco Simona, Michele Paola Di, Haupt Riccardo, Boni Luca, Pigullo Simona, Dufour Carlo, Garaventa Alberto, Tonini Gian Paolo
Abstract excerpt
There is evidence to suggest that polymorphic variations in the glutathione S-transferase (GSTs) are associated with cancer susceptibility. The GST supergene family includes several genes with well characterized polymorphisms. Approximately 50% of the Caucasian population is homozygous for deletions in GSTM1 and approximately 20% are homozygous for deletions in GSTT1. Deletions lead to an absence of the protein,...
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