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Article

Relative impact of CYP3A genotype and concomitant medication on the severity of atorvastatin-induced muscle damage.

Pharmacogenetics and genomics - 1 Jun 2005

Wilke Russell A, Moore Jason H, Burmester James K

Abstract excerpt

Atorvastatin is metabolized through enzymes encoded by members of the cytochrome P-450 (CYP) 3A gene family. Some patients who take atorvastatin along with concomitant medications known to inhibit CYP3A enzyme activity (e.g. itraconazole) develop rhabdomyolysis secondary to a severe drug-induced myopathy. The present study aimed to characterize the relationship between CYP3A gene polymorphisms and...

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Identifiers

PMID: 15900215
DOI: 10.1097/01213011-200506000-00007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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