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Article

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein.

Cancer research - 15 May 2005

Chung Ji-Hyun, Ginn-Pease Margaret E, Eng Charis

Abstract excerpt

Although phosphatase and tensin homologue deleted on chromosome 10 (PTEN) localization in the nucleus and cytoplasm is established, the mechanism is unknown. PTEN is a tumor suppressor phosphatase that causes cell cycle arrest and/or apoptosis. Nuclear-cytoplasmic compartmentalization may be a novel mechanism in regulating these events. PTEN does not contain a traditional nuclear localization sequence (NLS);...

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Share to Cell Nucleus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nuclear Localization Signals

Share to Phosphoric Monoester Hydrolases

Share to PTEN Phosphohydrolase

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Source

Identifiers

PMID: 15899801
DOI: 10.1158/0008-5472.CAN-05-0124

Genes

PTEN
MVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein.PMID 15899801Read ↗

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