Article
Apolipoprotein E haplotyping by denaturing high-performance liquid chromatography.
Clinical chemistry and laboratory medicine - 1 Jan 2005
Poli Maura, Gatta Luisa Benerini, Dominici Roberto, Lovati Carlo, Mariani Claudio, Albertini Alberto, Finazzi Dario
Abstract excerpt
The apolipoprotein E ( APOE ) gene in humans contains two single-base polymorphisms in exon 4, which result in three common alleles, conventionally named epsilon2 , epsilon3 and epsilon4 . Numerous studies have shown an important association between the epsilon4 variant and an increased risk of Alzheimer's disease; other data suggest a possible linkage of APOE genetic heterogeneity with lipid profile and an...
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