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Article

Neuroprotective effect of oxidized galectin-1 in a transgenic mouse model of amyotrophic lateral sclerosis.

Experimental neurology - 1 Jul 2005

Chang-Hong Ren, Wada Manabu, Koyama Shingo, Kimura Hideki, Arawaka Shigeki, Kawanami Toru, Kurita Keiji, Kadoya Toshihiko, Aoki Masashi, Itoyama Yasuto, Kato Takeo

Abstract excerpt

Abnormal accumulation of neurofilaments in motor neurons is a characteristic pathological finding in amyotrophic lateral sclerosis (ALS). Recently, we revealed that galectin-1, whose oxidized form has axonal regeneration-enhancing activity, accumulates in the neurofilamentous lesions in ALS. To investigate whether oxidized galectin-1 has a beneficial effect on ALS, oxidized recombinant human galectin-1...

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Identifiers

PMID: 15899257
DOI: 10.1016/j.expneurol.2005.02.011

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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