Article
Lack of an association between 5-HT receptor gene polymorphisms and suicide victims.
Psychiatry and clinical neurosciences - 1 Jun 2005
Okamura Kenji, Shirakawa Osamu, Nishiguchi Naoki, Ono Hisae, Nushida Hideyuki, Ueno Yasuhiro, Maeda Kiyoshi
Abstract excerpt
An association between serotonergic dysfunction in the brain and suicidal behavior has previously been suggested. The high affinity of some antipsychotic and antidepressant drugs to serotonin 6 (5-HT6) receptors, and the predominant localization of 5-HT6 receptors in some limbic regions, suggest that 5-HT6 receptors play a role in the pathogenesis of suicide. The objective of the present study was to examine the...
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