Article
Connexin levels regulate keratinocyte differentiation in the epidermis.
The Journal of biological chemistry - 12 Oct 2007
Langlois Stéphanie, Maher Amy C, Manias Janet L, Shao Qing, Kidder Gerald M, Laird Dale W
Abstract excerpt
To understand the role of connexin43 (Cx43) in epidermal differentiation, we reduced Cx43 levels by RNA-mediated interference knockdown and impaired its functional status by overexpressing loss-of-function Cx43 mutants associated with the human disease oculodentodigital dysplasia (ODDD) in rat epidermal keratinocytes. When Cx43 expression was knocked down by 50-75%, there was a coordinate 55-65% reduction in Cx26...
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