Article
Connexin31-deficiency in mice causes transient placental dysmorphogenesis but does not impair hearing and skin differentiation.
Developmental biology - 15 Mar 2001
Plum A, Winterhager E, Pesch J, Lautermann J, Hallas G, Rosentreter B, Traub O, Herberhold C, Willecke K
Abstract excerpt
Mutations in the human GJB3 gene that codes for Connexin31 (Cx31), a protein subunit of gap junction channels, have recently been reported to cause deafness and the skin disorder erythrokeratodermia variabilis. To study the function of this gene in mice, we generated animals with targeted replacement of the Cx31 gene (Gjb3) by a lacZ reporter gene. Although homozygous Cx31-deficient adult mice (Gjb3(-/-)) were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.