Article
Identification and characterisation of two runx2 homologues in zebrafish with different expression patterns.
Biochimica et biophysica acta - 30 Jun 2005
van der Meulen T, Kranenbarg S, Schipper H, Samallo J, van Leeuwen J L, Franssen H
Abstract excerpt
Genome and gene duplications are considered to be the impetus to generate new genes, as the presence of multiple copies of a gene allows for paralogues to adopt novel function. After at least two rounds of genome/gene duplication, the Runt gene family consists of three members in vertebrates, instead of one in invertebrates. One of the family members, Runx2, plays a key role in the development of bone, a tissue...
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