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Article

Enzymatic regulation of methionine/homocysteine levels by the folate pathway dictates broad-spectrum defense in Arabidopsis.

International journal of biological macromolecules - 1 Apr 2026

Pati Debasish, Sultan Eram, Naik Arya Kumar Dibyananda, Kesh Rishi, Sahu Binod Bihari

Abstract excerpt

Folate-dependent one‑carbon (1C) metabolism is vital for plant development and stress responses, but its specific role in immunity remains unclear. Arabidopsis Methylenetetrahydrofolate reductase 2 (MTHFR2), a prominent enzyme in 1C metabolism, is crucial in regulating methionine biosynthesis and controlling broad-spectrum immunity. Here, we show by HRMS profiling that loss-of-function mutation in MTHFR2 disturbs...

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PMID: 41937012
DOI: 10.1016/j.ijbiomac.2026.151845

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