Article
Progressive loss of the spongiotrophoblast layer of Birc6/Bruce mutants results in embryonic lethality.
Genesis (New York, N.Y. : 2000) - 1 Jun 2005
Hitz Christiane, Vogt-Weisenhorn Daniela, Ruiz Patricia, Wurst Wolfgang, Floss Thomas
Abstract excerpt
We have generated a mouse line with a mutant allele of the mouse Bruce/Birc6 gene induced by gene trap mutagenesis. Based on its structural features, Bruce is a member of the family of apoptosis inhibitor proteins (IAPs). This mutation leads to a truncated transcript and protein and results in a complete loss of the wildtype Bruce protein. Bruce mutant mice die from a progressive loss of their placental...
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